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Biodegradable Polymer

Nobori® drug eluting stent has a unique design with an asymmetric coating and biodegradable polymer.
The biodegradable PLA (Polylactid Acid) is a naturally occurring polymer with a long history of medical applications.
This innovative concept allows for simultaneous polymer degradation and drug release.

Key Characteristics

Abluminal Coating

Fully Biodegradable Polymer

By applying only abluminal (outer surface) coating the Nobori® new generation drug eluting stent allows for:

Targeted drug release into the vessel wall
Minimal systemic effect
Better stent endothelialization with possible positive impact on safety

PLA completely degrades by hydrolysis to carbon dioxide and water. Degradation of the polymer may improve long term safety by:

Reducing chronic sensitivity
Eliminating the potential problem of remnant drug inside the coating
Abolishing chances of delamination or late failure of coating

Biodegradable polymer on abluminal surface preserves endothelial function

PLA bioabsorbable Polymer

Abluminal Coating
High drug-carrying capacity
Controlled biodegradability
Simultaneous polymer degradation
and release of drug into tissue

1 Ostojic M et al:The pharmacokinetics of Biolimus A9™ after elution from the Nobori® stent in patients with coronary artery disease: the NOBORI PK study.Catheter Cardiovasc Interv. 2008 Dec

2 Hamilos M et al.: Differential effects of drug-eluting stents on local endothelium-dependent coronary vasomotion. J Am Coll Cardiol 2008; 2008;51:2123-9

Pictures taken by Terumo

Biolimus A9 (™ - by Biosensors)